After two more flops she had her breakthrough role with Musafir. The film eventually flopped but it made it clear that Sameera Reddy had arrived. She went from shy college girl to ultimate sex symbol. Her stunning image and sensuality was enough to get her noticed. The film was quite controversial as it included a kissing scene between her and her co-star Anil Kapoor.Her sister, Sushma Reddy made her acting debut with the film Chocolate. Her elder sister is Meghna Reddy.She made a guest appearance on the British show Casualty.